{"id":11224,"date":"2015-04-07T12:00:26","date_gmt":"2015-04-07T12:00:26","guid":{"rendered":"https:\/\/www.giztab.com\/?p=11224"},"modified":"2015-04-07T13:49:00","modified_gmt":"2015-04-07T13:49:00","slug":"crean-vacuna-que-aumenta-resistencia-frente-al-cancer","status":"publish","type":"post","link":"https:\/\/www.giztab.com\/crean-vacuna-que-aumenta-resistencia-frente-al-cancer\/","title":{"rendered":"Crean vacuna que aumenta resistencia frente al c\u00e1ncer"},"content":{"rendered":"<p>Un nueva vacuna est\u00e1 siendo probada para mejorar la respuesta inmunitaria en pacientes con <a href=\"https:\/\/www.giztab.com\/?s=c%C3%A1ncer\" target=\"_blank\">c\u00e1ncer<\/a>. El preparado que contiene <strong>prote\u00ednas alteradas<\/strong> del tumor del paciente, es una luz para las personas que padecen la enfermedad en \u00f3rganos como pulm\u00f3n, vejiga y colon, adem\u00e1s de mutaciones como el melanoma.<\/p>\n<p>La especialista venezolana en Microbiolog\u00eda, Neuroinmunolog\u00eda y Gen\u00e9tica, <a href=\"http:\/\/oncology.wustl.edu\/people\/faculty\/Carreno\/Carreno_Bio.html\" target=\"_blank\">Beatr\u00edz Carre\u00f1o<\/a>, lidera desde la <a href=\"http:\/\/medicine.wustl.edu\/\" target=\"_blank\">Washington University School of Medicine<\/a>, en EEUU, los estudios que han comprobado que el uso de prote\u00ednas alteradas del paciente con tumor \u201cprovocan una mayor reacci\u00f3n en las <strong>c\u00e9lulas T<\/strong>, al multiplicar en n\u00famero y frecuencia su capacidad de reconocer sustancias aisladas de los tumores\u201d.<\/p>\n<p>Las c\u00e9lulas T son, seg\u00fan <a href=\"http:\/\/es.wikipedia.org\/wiki\/Linfocito_T\" target=\"_blank\">Wikipedia<\/a>, \u201cresponsables de coordinar la respuesta inmune celular constituyendo el 70% del total de los linfocitos que segregan prote\u00ednas o citocinas. Tambi\u00e9n se ocupan de realizar la cooperaci\u00f3n para desarrollar todas las formas de respuestas inmunes, como la producci\u00f3n de anticuerpos por los linfocitos B\u201d. Estas c\u00e9lulas tendr\u00edan efectos importantes en los tumores y otras c\u00e9lulas infectadas con virus.<\/p>\n<p>La revista cient\u00edfica <a href=\"http:\/\/www.sciencemag.org\/content\/early\/2015\/04\/01\/science.aaa3828.abstract?sid=b1bbdc02-25df-4b75-9453-907a5526e34b\" target=\"_blank\">Science<\/a>, se ha hecho eco de esta investigaci\u00f3n y publica que para la elaboraci\u00f3n de la vacuna fueron utilizadas <strong>c\u00e9lulas dendr\u00edticas<\/strong> que se sumaron a las prote\u00ednas alteradas del tumor del paciente. Los investigadores aislaron precursores de estas c\u00e9lulas y las cultivaron en el laboratorio debido a que no son muy abundantes en el organismo.<\/p>\n<p>La Profesora Carre\u00f1o ha comentado que las vacunas que han sido ya desarrolladas contra el c\u00e1ncer, son com\u00fanmente generalizadas y su respuesta inmune no es muy fuerte. No es ese el caso de la que se elabora bajo su cargo, la cual vendr\u00eda a ser de las primeras personalizadas y tendr\u00eda buenos resultados en pacientes con tipos de <a href=\"https:\/\/www.giztab.com\/?s=c%C3%A1ncer\" target=\"_blank\">c\u00e1ncer<\/a> que tengan alto componente inmunol\u00f3gico y mutaciones, tales como los de pulm\u00f3n, vejiga, colon y el melanoma.<\/p>\n<blockquote><p>\u201cEl uso de prote\u00ednas alteradas ha demostrado tener una mayor capacidad para activar el sistema inmune, porque cuando las prote\u00ednas son normales, no son realmente sustancias extra\u00f1as y, por tanto, la respuesta inmune no es muy fuerte. A mayor n\u00famero de mutaciones, encontramos m\u00e1s prote\u00ednas alteradas que podemos usar para activar el sistema inmune. Estamos hablando de una nueva manera de atacar el c\u00e1ncer, con la informaci\u00f3n gen\u00f3mica de los tumores. Usamos las alteraciones en el tumor para acelerar el sistema inmune\u201d.<\/p><\/blockquote>\n<p>Hasta el momento esta inmunoterapia se ha probado en tres pacientes, sin embargo se espera que signifique un gran avance para el tratamiento del <a href=\"https:\/\/www.giztab.com\/?s=c%C3%A1ncer\" target=\"_blank\">c\u00e1ncer<\/a> y las vacunas personalizadas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Una venezolana encabeza la investigaci\u00f3n sobre inmunoterapia contra el c\u00e1ncer que puede resultar positiva en casos espec\u00edficos de pulm\u00f3n, vejiga, colon y melanoma.<\/p>\n","protected":false},"author":37,"featured_media":11226,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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